Runx Family Genes in a Cartilaginous Fish, the Elephant Shark (Callorhinchus milii)

Abstract

The Runx family genes encode transcription factors that play key roles in hematopoiesis, skeletogenesis and neurogenesis and are often implicated in diseases. We describe here the cloning and characterization of Runx1, Runx2, Runx3 and Runxb genes in the elephant shark (Callorhinchus milii), a member of Chondrichthyes, the oldest living group of jawed… (More)
DOI: 10.1371/journal.pone.0093816

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