Runt-related Transcription Factor 1 (RUNX1) Binds to p50 in Macrophages and Enhances TLR4-triggered Inflammation and Septic Shock.

@article{Luo2016RuntrelatedTF,
  title={Runt-related Transcription Factor 1 (RUNX1) Binds to p50 in Macrophages and Enhances TLR4-triggered Inflammation and Septic Shock.},
  author={Mao-Cai Luo and Si-yuan Zhou and Dan-Ying Feng and Jun Xiao and Wei-yun Li and Chun-Di Xu and Hong-yan Wang and Tong Zhou},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 42},
  pages={22011-22020}
}
An appropriate inflammatory response plays critical roles in eliminating pathogens, whereas an excessive inflammatory response can cause tissue damage. Runt-related transcription factor 1 (RUNX1), a master regulator of hematopoiesis, plays critical roles in T cells; however, its roles in Toll-like receptor 4 (TLR4)-mediated inflammation in macrophages are unclear. Here, we demonstrated that upon TLR4 ligand stimulation by lipopolysaccharide (LPS), macrophages reduced the expression levels of… CONTINUE READING