Runt-Related Transcription Factor 2 Induction During Differentiation of Wharton's Jelly Mesenchymal Stem Cells to Osteoblasts Is Regulated by Jumonji AT-Rich Interactive Domain 1B Histone Demethylase.

@article{Bustos2017RuntRelatedTF,
  title={Runt-Related Transcription Factor 2 Induction During Differentiation of Wharton's Jelly Mesenchymal Stem Cells to Osteoblasts Is Regulated by Jumonji AT-Rich Interactive Domain 1B Histone Demethylase.},
  author={Francisco Bustos and Hugo Sep{\'u}lveda and Catalina P. Prieto and Margarita Carrasco and Lorena Carvajal D{\'i}az and Jos{\'e} Palma and Jos{\'e} Lattus and Mart{\'i}n A. Montecino and Ver{\'o}nica Palma},
  journal={Stem cells},
  year={2017},
  volume={35 12},
  pages={
          2430-2441
        }
}
Novel bone regeneration approaches aim to obtain immature osteoblasts from somatic stem cells. Umbilical cord Wharton's jelly mesenchymal stem cells (WJ-MSCs) are an ideal source for cell therapy. Hence, the study of mechanisms involved in WJ-MSC osteoblastic differentiation is crucial to exploit their developmental capacity. Here, we have assessed epigenetic control of the Runt-related transcription factor 2 (RUNX2) osteogenic master regulator gene in WJ-MSC. We present evidence indicating… CONTINUE READING
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