Runs of homozygosity: windows into population history and trait architecture

@article{Ceballos2018RunsOH,
  title={Runs of homozygosity: windows into population history and trait architecture},
  author={Francisco C. Ceballos and Peter K Joshi and David W. Clark and Mich{\'e}le Ramsay and James F Wilson},
  journal={Nature Reviews Genetics},
  year={2018},
  volume={19},
  pages={220-234}
}
Long runs of homozygosity (ROH) arise when identical haplotypes are inherited from each parent and thus a long tract of genotypes is homozygous. Cousin marriage or inbreeding gives rise to such autozygosity; however, genome-wide data reveal that ROH are universally common in human genomes even among outbred individuals. The number and length of ROH reflect… CONTINUE READING