Running wheel activity is sensitive to acute treatment with selective inhibitors for either serotonin or norepinephrine reuptake

  title={Running wheel activity is sensitive to acute treatment with selective inhibitors for either serotonin or norepinephrine reuptake},
  author={M. Weber and S. Talmon and I. Schulze and C. Boeddinghaus and G. Gross and H. Schoemaker and K. Wicke},
  • M. Weber, S. Talmon, +4 authors K. Wicke
  • Published 2008
  • Medicine
  • Psychopharmacology
  • RationaleMost antidepressants (AD) directly or indirectly enhance the serotonergic tone in the CNS. Since the serotonin system is involved in both, the modulation of mood and motor behavior, it was reasoned that these drugs might also interfere with running wheel activity (RWA), a form of positively motivated motor behavior, which might be linked to pathological states like obsessive–compulsive disorder (OCD).ObjectivesWe used RWA to characterize ADs from all major classes. Effects on RWA were… CONTINUE READING
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