Corpus ID: 53553748

Running title : Autophagy related markers ( Beclin-1 and ATG 4 B )

  title={Running title : Autophagy related markers ( Beclin-1 and ATG 4 B )},
  author={Maha Guimei and Mohamed Ahmed Eladl and Anu Vinod Ranade and Shaista Manzoor},


The presence of LC3B puncta and HMGB1 expression in malignant cells correlate with the immune infiltrate in breast cancer
Combined analysis of LC3B puncta and HMGB1 expression allowed for improved stratification of patients with respect to the characteristics of their immune infiltrate as well as overall and metastasis-free survival. Expand
The role for autophagy in cancer.
  • E. White
  • Biology, Medicine
  • The Journal of clinical investigation
  • 2015
Mechanisms by which autophagy promotes cancer include suppressing induction of the p53 tumor suppressor protein and maintaining metabolic function of mitochondria. Expand
Wilms' tumor
Survival for patients with Wilms' tumor when considered as a whole, once less than 30%, is currently greater than 90%, with this dramatic improvement being due, in part, to the systematic manner in which the approach to therapy has evolved. Expand
SQSTM1 is a pathogenic target of 5q copy number gains in kidney cancer.
It is shown that 5q amplification leads to overexpression of the SQSTM1 oncogene in ccRCC lines and tumors, and the selection pressure to amplify 5q inccRCC is driven, at least partly, by SQ STM1. Expand
Autophagy: Renovation of Cells and Tissues
It is explored how recent mouse models in combination with advances in human genetics are providing key insights into how the impairment or activation of autophagy contributes to pathogenesis of diverse diseases, from neurodegenerative diseases such as Parkinson disease to inflammatory disorders such as Crohn disease. Expand
Expression analysis of LC3B and p62 indicates intact activated autophagy is associated with an unfavorable prognosis in colon cancer
These specific expression patterns of LC3B and p62 pointing to different states of autophagy associated with diverging clinical outcomes highlighte the potential significance of basal Autophagy in CC biology. Expand
p53 upregulates PLCε-IP3-Ca2+ pathway and inhibits autophagy through its target gene Rap2B.
It is demonstrated that p53 increases the intracellular IP3 and Ca2+ levels and decreases the LC3 protein levels through its target gene Rap2B, suggesting that p 53 can inhibit the autophagic response triggered by starvation via upregulation of the Rap2 B-PLCε-IP3-Ca2+ pathway. Expand
Clinical significance of the expression of autophagy-associated marker, beclin 1, in breast cancer patients who received neoadjuvant endocrine therapy
It is demonstrated that beclin 1 and LC3 immunoreactivity increased in carcinoma cells following exemestane treatment and that the status of pre-treatment stromal beClin 1 is associated with higher carcinoma cell proliferation and poor clinical and pathological responses to NAE. Expand
Expression and clinical significance of Beclin-1 in gastric cancer tissues of various clinical stages.
In vivo and in vitro experiments indicated that in gastric cancer tissues, autophagy was downregulated following the development of cancer tissue and that inflammation may be a significant factor in this process. Expand
Histopathological and Molecular Characteristics of Wilms Tumor
In this chapter, histopathological features of WT, genetic and molecular modifications related to WT, the effects of these genetic abnormalities on prognosis, and clues for differential diagnosis were evaluated. Expand