Corpus ID: 53553748

Running title : Autophagy related markers ( Beclin-1 and ATG 4 B )

@inproceedings{Guimei2018RunningT,
  title={Running title : Autophagy related markers ( Beclin-1 and ATG 4 B )},
  author={Maha Guimei and Mohamed Ahmed Eladl and Anu Vinod Ranade and Shaista Manzoor},
  year={2018}
}

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TLDR
Combined analysis of LC3B puncta and HMGB1 expression allowed for improved stratification of patients with respect to the characteristics of their immune infiltrate as well as overall and metastasis-free survival. Expand
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Mechanisms by which autophagy promotes cancer include suppressing induction of the p53 tumor suppressor protein and maintaining metabolic function of mitochondria. Expand
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Survival for patients with Wilms' tumor when considered as a whole, once less than 30%, is currently greater than 90%, with this dramatic improvement being due, in part, to the systematic manner in which the approach to therapy has evolved. Expand
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TLDR
It is explored how recent mouse models in combination with advances in human genetics are providing key insights into how the impairment or activation of autophagy contributes to pathogenesis of diverse diseases, from neurodegenerative diseases such as Parkinson disease to inflammatory disorders such as Crohn disease. Expand
Expression analysis of LC3B and p62 indicates intact activated autophagy is associated with an unfavorable prognosis in colon cancer
TLDR
These specific expression patterns of LC3B and p62 pointing to different states of autophagy associated with diverging clinical outcomes highlighte the potential significance of basal Autophagy in CC biology. Expand
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TLDR
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In vivo and in vitro experiments indicated that in gastric cancer tissues, autophagy was downregulated following the development of cancer tissue and that inflammation may be a significant factor in this process. Expand
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