Running the gamut of retroviral variation.


The retroviral DNA polymerase, or reverse transcriptase, lacks a 3' exonuclease proofreading activity. This causes a high mutation rate with the result that genetic diversity and drug resistance are increased. Only combination chemotherapy has the potential to out-manoeuvre these viruses. However, there is no evidence that ongoing variation allows escape… (More)


Cite this paper

@article{WainHobson1996RunningTG, title={Running the gamut of retroviral variation.}, author={Simon Wain-Hobson}, journal={Trends in microbiology}, year={1996}, volume={4 4}, pages={135-41} }