Running promotes wakefulness and increases cataplexy in orexin knockout mice.

@article{Espaa2007RunningPW,
  title={Running promotes wakefulness and increases cataplexy in orexin knockout mice.},
  author={Rodrigo A Espa{\~n}a and Sarah L McCormack and Takatoshi Mochizuki and Thomas E Scammell},
  journal={Sleep},
  year={2007},
  volume={30 11},
  pages={1417-25}
}
STUDY OBJECTIVE People with narcolepsy and mice lacking orexin/hypocretin have disrupted sleep/wake behavior and reduced physical activity. Our objective was to identify physiologic mechanisms through which orexin deficiency reduces locomotor activity. DESIGN We examined spontaneous wheel running activity and its relationship to sleep/wake behavior in wild type (WT) and orexin knockout (KO) mice. Additionally, given that physical activity promotes alertness, we also studied whether orexin… CONTINUE READING