Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

@article{Praag1999RunningIC,
  title={Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus},
  author={Henriette van Praag and Gerd Kempermann and Fred H. Gage},
  journal={Nature Neuroscience},
  year={1999},
  volume={2},
  pages={266-270}
}
Exposure to an enriched environment increases neurogenesis in the dentate gyrus of adult rodents. [] Key Method We attempted to separate components by assigning adult mice to various conditions: water-maze learning (learner), swim-time-yoked control (swimmer), voluntary wheel running (runner), and enriched (enriched) and standard housing (control) groups. Neither maze training nor yoked swimming had any effect on bromodeoxyuridine (BrdU)-positive cell number. However, running doubled the number of surviving…
Running enhances neurogenesis, learning, and long-term potentiation in mice.
TLDR
The results indicate that physical activity can regulate hippocampal neurogenesis, synaptic plasticity, and learning.
Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis
TLDR
The discrepancy between the olfactory bulb and the dentate gyrus suggests that these living conditions trigger locally through an as yet unidentified mechanism specific to neurogenic signals in the dentates gyrus.
Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running.
TLDR
Evidence is shown that neurogenesis can occur without learning enhancement in mice selectively bred for high levels of wheel running, which is the first evidence that Neurogenesis could occur without enhancement.
Running is the neurogenic and neurotrophic stimulus in environmental enrichment.
TLDR
It is concluded that exercise is the critical factor mediating increased BDNF levels and adult hippocampal neurogenesis, and new cell proliferation, survival, neuron number, and neurotrophin levels were enhanced only when running was accessible.
Distinct stages of adult hippocampal neurogenesis are regulated by running and the running environment
TLDR
It is demonstrated that exposure to a running wheel environment, in the absence of running, is sufficient for promoting proliferation of early lineage hippocampal precursors, while running per se enables newly generated neuroblasts to survive and mature into functional hippocampal neurons.
Additive Effects of Physical Exercise and Environmental Enrichment on Adult Hippocampal Neurogenesis in Mice
TLDR
It is proposed that physical activity can “prime” the neurogenic region of the dentate gyrus for increased neurogenesis in the case the animal is exposed to an additional cognitive stimulus, here represented by the enrichment paradigm.
Regulation of Adult Neurogenesis by Environment and Learning
TLDR
The key idea is that activity-dependent regulation of adult neurogenesis allows lifelong optimization of the mossy fiber connection, presumably allowing the system to efficiently respond to novelty and complexity encountered by the individual.
Forced running enhances neurogenesis in the hippocampal dentate gyrus of adult rats and improves learning ability.
TLDR
It is suggested that forced running in motor-driven wheel could enhance neurogenesis in the hippocampal DG of adult rats and improve learning ability.
Running wheel exercises accelerate neuronal turnover in mouse dentate gyrus
...
...

References

SHOWING 1-10 OF 64 REFERENCES
Experience-Induced Neurogenesis in the Senescent Dentate Gyrus
TLDR
It is demonstrated here that under physiological conditions neurogenesis continues to occur in the dentate gyrus of senescent mice and can be stimulated by living in an enriched environment and interpreted as a survival-promoting effect that is selective for neurons.
Learning enhances adult neurogenesis in the hippocampal formation
TLDR
It is reported that the number of adult-generated neurons doubles in the rat dentate gyrus in response to training on associative learning tasks that require the hippocampus, which indicates that adult- generated hippocampal neurons are specifically affected by, and potentially involved in, associative memory formation.
Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation
TLDR
It is confirmed that in the adult rat brain, neuronal progenitor cells divide at the border between the hilus and the granule cell layer (GCL) and in adult rats, the progeny of these cells migrate into the GCL and express the neuronal markers NeuN and calbindin-D28k.
Genetic influence on neurogenesis in the dentate gyrus of adult mice.
TLDR
The results show that different aspects of adult hippocampal neurogenesis are differentially influenced by the genetic background.
Selective loss of hippocampal granule cells following adrenalectomy: implications for spatial memory
  • CD Conrad, EJ Roy
  • Biology, Psychology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1993
TLDR
Damage to the dentate gyrus following long-term ADX is severe enough to cause learning impairment in selected learning tasks, and can occur throughout the rostrocaudal regions of the hippocampus.
Spatial learning induces neurogenesis in the avian brain
Neurogenesis in the adult human hippocampus
TLDR
It is demonstrated that new neurons, as defined by these markers, are generated from dividing progenitor cells in the dentate gyrus of adult humans, indicating that the human hippocampus retains its ability to generate neurons throughout life.
Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress.
TLDR
The results suggest that neurons are produced in the dentate gyrus of adult monkeys and that the rate of precursor cell proliferation can be affected by a stressful experience.
...
...