Running exercise delays neurodegeneration in amygdala and hippocampus of Alzheimer’s disease (APP/PS1) transgenic mice

@article{Lin2015RunningED,
  title={Running exercise delays neurodegeneration in amygdala and hippocampus of Alzheimer’s disease (APP/PS1) transgenic mice},
  author={Tzu-Wei Lin and Yao-Hsiang Shih and Shean-Jen Chen and Chi-Hsiang Lien and Yu-Min Kuo},
  journal={Neurobiology of Learning and Memory},
  year={2015},
  volume={118},
  pages={189-197}
}
Alzheimer's disease (AD) is an age-related neurodegenerative disease. Post-mortem examination and brain imaging studies indicate that neurodegeneration is evident in the hippocampus and amygdala of very early stage AD patients. Exercise training is known to enhance hippocampus- and amygdala-associated neuronal function. Here, we investigated the effects of exercise (running) on the neuronal structure and function of the hippocampus and amygdala in APP/PS1 transgenic (Tg) mice. At 4-months-old… CONTINUE READING
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