Running and cocaine both upregulate dynorphin mRNA in medial caudate putamen.

@article{Werme2000RunningAC,
  title={Running and cocaine both upregulate dynorphin mRNA in medial caudate putamen.},
  author={Martin Werme and Peter Thor{\'e}n and Lars Olson and Stefan Bren{\'e}},
  journal={The European journal of neuroscience},
  year={2000},
  volume={12 8},
  pages={
          2967-74
        }
}
Physical activities such as long-distance running can be habit forming and associated with a sense of well-being to a degree that justifies comparison with drug-induced addictive behaviours. To understand molecular similarities and dissimilarities controlling these behaviours in humans we compared the effects of running in running wheels to the effects of chronic cocaine or morphine administration on mRNA levels in brain reward pathways in the inbred Fischer and Lewis rat strains. These strains… CONTINUE READING
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