Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn’s disease, produces an inflammatory polysaccharide

@inproceedings{Henke2019RuminococcusGA,
  title={Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn’s disease, produces an inflammatory polysaccharide},
  author={Matthew T Henke and Douglas J Kenny and Chelsi D Cassilly and Hera Vlamakis and Ramnik J. Xavier and Jon Clardy},
  booktitle={Proceedings of the National Academy of Sciences of the United States of America},
  year={2019}
}
A substantial and increasing number of human diseases are associated with changes in the gut microbiota, and discovering the molecules and mechanisms underlying these associations represents a major research goal. Multiple studies associate Ruminococcus gnavus, a prevalent gut microbe, with Crohn's disease, a major type of inflammatory bowel disease. We have found that R. gnavus synthesizes and secretes a complex glucorhamnan polysaccharide with a rhamnose backbone and glucose sidechains… CONTINUE READING

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