Ruling out SARS-CoV-2 infection using exhaled breath analysis by electronic nose in a public health setting

  title={Ruling out SARS-CoV-2 infection using exhaled breath analysis by electronic nose in a public health setting},
  author={Rianne de Vries and Ren{\'e} M. Vigeveno and Sije Mulder and Niloufar Farzan and D. R. Vintges and Jelle J. Goeman and S. Bruisten and B. van der Corput and J. J. Miranda Geelhoed and Leo G. Visser and Mariken van der Lubben and Peter J. Sterk and Johannes C C M in 't Veen and Geert H. Groeneveld},
  journal={American Journal of Respiratory and Critical Care Medicine},
Background: Rapid and accurate detection of SARS-CoV-2 infected individuals is crucial for taking timely measures and minimizing the risk of further SARS-CoV-2 spread. We aimed to assess the accuracy of exhaled breath analysis by electronic nose (eNose) for the discrimination between individuals with and without a SARS-CoV-2 infection. Methods: This was a prospective real-world study of individuals presenting to public test facility for SARS-CoV-2 detection by molecular amplification tests (TMA… 
5 Citations
Electronic and animal noses for detecting SARS-CoV-2 infection
This protocol is a protocol for a Cochrane Review (diagnostic) to assess the diagnostic test accuracy of eNoses to screen for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in public places, such as airports.
Comparative analysis of chemical breath-prints through olfactory technology for the discrimination between SARS-CoV-2 infected patients and controls
The use of olfactory technologies in communities having high transmission rates as well as in resource-limited settings where targeted sampling is not viable represents a practical COVID-19 screening approach capable of promptly identifying suspect patients and providing useful epidemiological information to guide community health strategies in the context of CO VID-19.
The Potential of Volatile Organic Compounds-Based Breath Analysis for COVID-19 Screening: A Systematic Review & Meta-Analysis
VOC-based breath analysis shows high sensitivity and promising specificity for COVID-19 public screening, compared to RT-PCR.
Recent Advances in Novel Lateral Flow Technologies for Detection of COVID-19
Recent advances in novel lateral flow technologies for detecting SARS-CoV-2 as well as innovative approaches to achieve highly sensitive and specific point-of-care testing are highlighted.
Use of emerging testing technologies and approaches for SARS-CoV-2: review of literature and global experience in an Australian context
Information detailing population-wide testing strategies for SARS-COV-2 is largely missing from peer-reviewed literature, and the strategic use of novel assays will help strike the balance between achieving adequate test numbers without overwhelming laboratory capacity.


Applying the electronic nose for pre-operative SARS-CoV-2 screening
The Aeonose can distinguish COVID-19 positive from negative participants based on VOC patterns in exhaled breath with a high NPV, and might be a promising, non-invasive, and low-cost triage tool for excluding SARS-CoV-2 infection in patients elected for surgery.
Rapid detection of SARS-CoV-2 infection by multicapillary column coupled ion mobility spectrometry (MCC-IMS) of breath. A proof of concept study
MCC-IMS of breath is able to detect SARS-CoV-2 infection and Influenza-A infection in breath and should be further developed for screening of communicable viral diseases.
Breath biomarkers of pediatric SARS-CoV-2 infection: a pilot study
This work hypothesizes that candidate biomarkers characterize the exhaled breath of children with SARS-CoV2 infection, and provides a solid framework upon which to build a future ''breathalyzer'' test for SARS -CoV-2 infection in children.
Diagnosis of COVID-19 by analysis of breath with gas chromatography-ion mobility spectrometry - a feasibility study
Patients with COVID-19 can be rapidly distinguished from patients with other conditions at first healthcare contact with near-patient gas chromatography-ion mobility spectrometry, and development and validation of this approach may allow rapid diagnosis of CO VID-19 in the coming endemic flu seasons.
Metabolomics of exhaled breath in critically ill COVID-19 patients: A pilot study
The real-time, non-invasive detection of methylpent-2-enal, 2,4-octadiene 1-chloroheptane, and nonanal in exhaled breath may identify ARDS patients with COVID-19.
The scent of COVID-19: viral (semi-)volatiles as fast diagnostic biomarkers?
Breath analysis could allow a fast differential diagnosis between SARS-COV-2, influenza or rhinovirus infection and hospitalize those patients with proven COVID-19 disease, where other patients can easily recover at home.
Multiplexed Nanomaterial-Based Sensor Array for Detection of COVID-19 in Exhaled Breath
A noninvasive approach in detecting and following-up individuals who are at-risk or have an existing COVID-19 infection, with a potential ability to serve as an epidemic control tool and a platform that could be applied for any other disease infection with proper modifications to the artificial intelligence.
Current Status of Laboratory Diagnosis for COVID-19: A Narrative Review
The current knowledge of direct and serological tests performed to research RNA, antigens, or antibodies for SARS-CoV-2 are summarized, evaluating the advantages and drawbacks for specific tests.
High-Throughput Transcription-mediated amplification on the Hologic Panther is a highly sensitive method of detection for SARS-CoV-2
A limit-of-detection study to assess the analytical sensitivity of TMA and RT-PCR concluded that TMA provides an effective, highly sensitive means of detection of SARS-CoV-2 in nasopharyngeal specimens.
Breath-borne VOC Biomarkers for COVID-19
The monitoring of ethyl butanoate, butyraldehyde and isopropanol could lend considerable support in rapidly screening CO VID-19; and alerting the presence of COVID-19 patient in particular environments.