Ruling out SARS-CoV-2 infection using exhaled breath analysis by electronic nose in a public health setting

@article{deVries2021RulingOS,
  title={Ruling out SARS-CoV-2 infection using exhaled breath analysis by electronic nose in a public health setting},
  author={Rianne de Vries and Ren{\'e} M. Vigeveno and Sije Mulder and Niloufar Farzan and D. R. Vintges and Jelle J. Goeman and S. M. Bruisten and B. van der Corput and J. J. Miranda Geelhoed and Leo G. Visser and Mariken van der Lubben and Peter J. Sterk and Johannes C C M in 't Veen and Geert H. Groeneveld},
  journal={TP91. TP091 EPIDEMIOLOGY AND TRANSLATIONAL ADVANCES IN SARS-COV-2},
  year={2021}
}
Background: Rapid and accurate detection of SARS-CoV-2 infected individuals is crucial for taking timely measures and minimizing the risk of further SARS-CoV-2 spread. We aimed to assess the accuracy of exhaled breath analysis by electronic nose (eNose) for the discrimination between individuals with and without a SARS-CoV-2 infection. Methods: This was a prospective real-world study of individuals presenting to public test facility for SARS-CoV-2 detection by molecular amplification tests (TMA… 

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References

SHOWING 1-10 OF 31 REFERENCES

Applying the electronic nose for pre-operative SARS-CoV-2 screening

TLDR
The Aeonose can distinguish COVID-19 positive from negative participants based on VOC patterns in exhaled breath with a high NPV, and might be a promising, non-invasive, and low-cost triage tool for excluding SARS-CoV-2 infection in patients elected for surgery.

Breath biomarkers of pediatric SARS-CoV-2 infection: a pilot study

TLDR
This work hypothesizes that candidate biomarkers characterize the exhaled breath of children with SARS-CoV2 infection, and provides a solid framework upon which to build a future ''breathalyzer'' test for SARS -CoV-2 infection in children.

Rapid detection of SARS-CoV-2 infection by multicapillary column coupled ion mobility spectrometry (MCC-IMS) of breath. A proof of concept study

TLDR
SARS-CoV-2 infection and influenza-A infection can be detected with the help of MCC-IMS in breath in this pilot study and should be further developed in a larger cohort for screening of communicable viral diseases.

The scent of COVID-19: viral (semi-)volatiles as fast diagnostic biomarkers?

TLDR
Breath analysis could allow a fast differential diagnosis between SARS-COV-2, influenza or rhinovirus infection and hospitalize those patients with proven COVID-19 disease, where other patients can easily recover at home.

Multiplexed Nanomaterial-Based Sensor Array for Detection of COVID-19 in Exhaled Breath

TLDR
A noninvasive approach in detecting and following-up individuals who are at-risk or have an existing COVID-19 infection, with a potential ability to serve as an epidemic control tool and a platform that could be applied for any other disease infection with proper modifications to the artificial intelligence.

Current Status of Laboratory Diagnosis for COVID-19: A Narrative Review

TLDR
The current knowledge of direct and serological tests performed to research RNA, antigens, or antibodies for SARS-CoV-2 are summarized, evaluating the advantages and drawbacks for specific tests.

Breath-borne VOC Biomarkers for COVID-19

TLDR
The monitoring of ethyl butanoate, butyraldehyde and isopropanol could lend considerable support in rapidly screening CO VID-19; and alerting the presence of COVID-19 patient in particular environments.