Ruling out SARS-CoV-2 infection using exhaled breath analysis by electronic nose in a public health setting

@article{deVries2021RulingOS,
  title={Ruling out SARS-CoV-2 infection using exhaled breath analysis by electronic nose in a public health setting},
  author={Rianne de Vries and Ren{\'e} M. Vigeveno and Sije Mulder and Niloufar Farzan and D. R. Vintges and Jelle J. Goeman and S. Bruisten and B. van der Corput and J. J. Miranda Geelhoed and Leo G. Visser and Mariken van der Lubben and Peter J. Sterk and Johannes C C M in 't Veen and Geert H. Groeneveld},
  journal={American Journal of Respiratory and Critical Care Medicine},
  year={2021},
  volume={203}
}
Background: Rapid and accurate detection of SARS-CoV-2 infected individuals is crucial for taking timely measures and minimizing the risk of further SARS-CoV-2 spread. We aimed to assess the accuracy of exhaled breath analysis by electronic nose (eNose) for the discrimination between individuals with and without a SARS-CoV-2 infection. Methods: This was a prospective real-world study of individuals presenting to public test facility for SARS-CoV-2 detection by molecular amplification tests (TMA… 
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References

SHOWING 1-10 OF 34 REFERENCES
Applying the electronic nose for pre-operative SARS-CoV-2 screening
TLDR
The Aeonose can distinguish COVID-19 positive from negative participants based on VOC patterns in exhaled breath with a high NPV, and might be a promising, non-invasive, and low-cost triage tool for excluding SARS-CoV-2 infection in patients elected for surgery.
Rapid detection of SARS-CoV-2 infection by multicapillary column coupled ion mobility spectrometry (MCC-IMS) of breath. A proof of concept study
TLDR
MCC-IMS of breath is able to detect SARS-CoV-2 infection and Influenza-A infection in breath and should be further developed for screening of communicable viral diseases.
Breath biomarkers of pediatric SARS-CoV-2 infection: a pilot study
TLDR
This work hypothesizes that candidate biomarkers characterize the exhaled breath of children with SARS-CoV2 infection, and provides a solid framework upon which to build a future ''breathalyzer'' test for SARS -CoV-2 infection in children.
Diagnosis of COVID-19 by analysis of breath with gas chromatography-ion mobility spectrometry - a feasibility study
TLDR
Patients with COVID-19 can be rapidly distinguished from patients with other conditions at first healthcare contact with near-patient gas chromatography-ion mobility spectrometry, and development and validation of this approach may allow rapid diagnosis of CO VID-19 in the coming endemic flu seasons.
Metabolomics of exhaled breath in critically ill COVID-19 patients: A pilot study
TLDR
The real-time, non-invasive detection of methylpent-2-enal, 2,4-octadiene 1-chloroheptane, and nonanal in exhaled breath may identify ARDS patients with COVID-19.
The scent of COVID-19: viral (semi-)volatiles as fast diagnostic biomarkers?
TLDR
Breath analysis could allow a fast differential diagnosis between SARS-COV-2, influenza or rhinovirus infection and hospitalize those patients with proven COVID-19 disease, where other patients can easily recover at home.
Multiplexed Nanomaterial-Based Sensor Array for Detection of COVID-19 in Exhaled Breath
TLDR
A noninvasive approach in detecting and following-up individuals who are at-risk or have an existing COVID-19 infection, with a potential ability to serve as an epidemic control tool and a platform that could be applied for any other disease infection with proper modifications to the artificial intelligence.
Current Status of Laboratory Diagnosis for COVID-19: A Narrative Review
TLDR
The current knowledge of direct and serological tests performed to research RNA, antigens, or antibodies for SARS-CoV-2 are summarized, evaluating the advantages and drawbacks for specific tests.
High-Throughput Transcription-mediated amplification on the Hologic Panther is a highly sensitive method of detection for SARS-CoV-2
TLDR
A limit-of-detection study to assess the analytical sensitivity of TMA and RT-PCR concluded that TMA provides an effective, highly sensitive means of detection of SARS-CoV-2 in nasopharyngeal specimens.
Breath-borne VOC Biomarkers for COVID-19
TLDR
The monitoring of ethyl butanoate, butyraldehyde and isopropanol could lend considerable support in rapidly screening CO VID-19; and alerting the presence of COVID-19 patient in particular environments.
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