Ruling Out or Ruling In Disease with the Most sensitiue or Specific Diagnostic Test

  title={Ruling Out or Ruling In Disease with the Most sensitiue or Specific Diagnostic Test},
  author={Edward J. Boyko},
  journal={Medical Decision Making},
  pages={175 - 179}
  • E. Boyko
  • Published 1 April 1994
  • Medicine
  • Medical Decision Making
Previous publications have advocated that clinicians choose the most sensitive diagnostic test to rule out disease and the most specific diagnostic test to rule in disease. This paper critically examines the validity of these recommendations. First, the author finds that following these recommendations does not lead to the highest disease probability for a positive test result (thereby best ruling in disease) or the lowest disease probability for a negative test result (thereby best ruling out… 

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