Rules of engagement: factors that regulate activity-dependent synaptic plasticity during neural network development.

@article{Stoneham2010RulesOE,
  title={Rules of engagement: factors that regulate activity-dependent synaptic plasticity during neural network development.},
  author={Emily T Stoneham and Erin Morgan Sanders and Mohima Sanyal and Theodore C Dumas},
  journal={The Biological bulletin},
  year={2010},
  volume={219 2},
  pages={81-99}
}
Overproduction and pruning during development is a phenomenon that can be observed in the number of organisms in a population, the number of cells in many tissue types, and even the number of synapses on individual neurons. The sculpting of synaptic connections in the brain of a developing organism is guided by its personal experience, which on a neural level translates to specific patterns of activity. Activity-dependent plasticity at glutamatergic synapses is an integral part of neuronal… CONTINUE READING

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