Rules for modeling signal-transduction systems.

  title={Rules for modeling signal-transduction systems.},
  author={William S. Hlavacek and James R. Faeder and Michael L. Blinov and Richard G. Posner and Michael Hucka and Walter Fontana},
  journal={Science's STKE : signal transduction knowledge environment},
  volume={2006 344},
Formalized rules for protein-protein interactions have recently been introduced to represent the binding and enzymatic activities of proteins in cellular signaling. Rules encode an understanding of how a system works in terms of the biomolecules in the system and their possible states and interactions. A set of rules can be as easy to read as a diagrammatic interaction map, but unlike most such maps, rules have precise interpretations. Rules can be processed to automatically generate a… CONTINUE READING


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