Rufinamide for the adjunctive treatment of partial seizures in adults and adolescents: A randomized placebo‐controlled trial

@article{Brodie2009RufinamideFT,
  title={Rufinamide for the adjunctive treatment of partial seizures in adults and adolescents: A randomized placebo‐controlled trial},
  author={Martin J Brodie and William E Rosenfeld and Blanca Vazquez and Rajesh C. Sachdeo and Carlos Perdomo and Allison Mann and Santiago Arroyo},
  journal={Epilepsia},
  year={2009},
  volume={50}
}
Purpose:  To evaluate efficacy and safety of adjunctive treatment with rufinamide 1600 mg twice daily in subjects aged ≥16 years with refractory partial seizures. 
A randomized, double‐blind, placebo‐controlled, parallel‐group study of rufinamide as adjunctive therapy for refractory partial‐onset seizures
Purpose:  Efficacy and safety of adjunctive rufinamide (3,200 mg/day) was assessed in adolescents and adults with inadequately controlled partial‐onset seizures receiving maintenance therapy with up
Rufinamide in children and adults in routine clinical practice
To explore the long‐term effectiveness of rufinamide in managing Lennox–Gastaut Syndrome (LGS), other epileptic encephalopathies, and intractable focal epilepsies in adults and children in routine
Rufinamide in refractory childhood epileptic encephalopathies other than Lennox–Gastaut syndrome
TLDR
This is the first multicenter Italian experience with rufinamide as adjunctive drug in children, adolescents and young adults with refractory childhood‐onset epileptic encephalopathies other than Lennox–Gastaut syndrome.
Safety and retention rate of rufinamide in 300 patients: A single pediatric epilepsy center experience
TLDR
This work evaluated the use of rufinamide in a single pediatric center with a large cohort and long‐term follow‐up period and found it to be safe and effective in children with refractory epilepsy.
Factors determining response to antiepileptic drugs in randomized controlled trials. A systematic review and meta‐analysis
TLDR
Meta‐analyses of placebo‐controlled randomized controlled trials of antiepileptic drugs in refractory partial epilepsy represent a potentially important source of evidence to guide treatment decisions, but such indirect comparisons raise various methodologic issues that may hamper their relevance.
Exposure to rufinamide and risks of CNS adverse events in drug‐resistant epilepsy: a meta‐analysis of randomized, placebo‐controlled trials
TLDR
Rufinamide is a drug used to treat partial‐onset seizures and seizures associated with Lennox‐Gastaut syndrome in adult and children and there has been no attempt to evaluate systematically the risks of adverse events.
Efficacy and safety of antiseizure medication for Lennox–Gastaut syndrome: a systematic review and network meta‐analysis
TLDR
To compare and rank the efficacy and safety of antiseizure medication (ASM) in patients with Lennox–Gastaut syndrome (LGS), a large number of patients with the disease have received treatment with ASM.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 24 REFERENCES
Systematic Review and Meta‐analysis of Incidence Studies of Epilepsy and Unprovoked Seizures
TLDR
To evaluate the methodology of incidence studies of epilepsy and unprovoked seizures and to assess the value of their findings by summarizing their results, a large number of studies reported positive results.
Adjunctive therapy with oxcarbazepine in children with partial seizures
TLDR
OXC adjunctive therapy administered in a dose range of 6 to 51 mg/kg/day (median 31.4 mg/ kg/day) is safe, effective, and well tolerated in children with partial seizures.
The prevalence of epilepsy and pharmacoresistant epilepsy in adults: A population‐based study in a Western European country
TLDR
To determine the prevalence of epilepsy in a defined adult population and identify the frequency and principal features of pharmacoresistant epilepsy, a large number of patients with known or suspected epilepsy are surveyed.
The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models
Purpose: To evaluate the anticonvulsant profile and behavioral toxicity of rufinamide in animal seizure models compared to the established antiepileptic drugs (AEDs): phenytoin, phenobarbital,
Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new onset epilepsy: Report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society
TLDR
The results of this evidence-based assessment provide guidelines for the prescription of AEDs for patients with newly diagnosed epilepsy and identify those seizure types and syndromes where more evidence is necessary.
Rufinamide for generalized seizures associated with Lennox–Gastaut syndrome
TLDR
Rufinamide was an effective and well-tolerated treatment for seizures associated with Lennox–Gastaut syndrome and had a greater improvement in seizure severity than placebo.
The Effect of the New Antiepileptic Drug Rufinamide on Cognitive Functions
Summary:  Purpose: Rufinamide (RUF 331; 1‐(2,6‐difluoro‐phenyl)methyl‐1H‐1,2,3‐triazole‐4‐carboxamide) is a structurally novel compound that limits the frequency of sodium‐dependent neuronal action
Modern antiepileptic drugs: guidelines and beyond
TLDR
The introduction of 10 new antiepileptic drugs has provided greater choice for patients and doctors, although evidence in support of their superiority over the older drugs is sparse, which has led to conflicting advice in guidelines.
Effects of Antiepileptic Drugs on Cognition
TLDR
Cognitive side effects of treatment with antiepileptic drugs (AEDs) are considered to be mild to moderate for most of the AEDs, but their impact may be substantial in some patients when critical functions are involved, such as learning in children or driving capacities in adults.
...
1
2
3
...