Rudimentary TCR signaling triggers default IL-10 secretion by human Th1 cells.

@article{Burrows2001RudimentaryTS,
  title={Rudimentary TCR signaling triggers default IL-10 secretion by human Th1 cells.},
  author={Gregory G. Burrows and Yuan Chou and Chyung-Ru Wang and Justin W. Chang and Thomas P. Finn and Nicole E. Culbertson and Jongsun Kim and Dennis N. Bourdette and David M Lewinsohn and Masato Ikeda and Takashi Yoshioka and Charles N. Allen and Halina Offner and Arthur A. Vandenbark},
  journal={Journal of immunology},
  year={2001},
  volume={167 8},
  pages={4386-95}
}
Understanding the process of inducing T cell activation has been hampered by the complex interactions between APC and inflammatory Th1 cells. To dissociate Ag-specific signaling through the TCR from costimulatory signaling, rTCR ligands (RTL) containing the alpha1 and beta1 domains of HLA-DR2b (DRA*0101:DRB1*1501) covalently linked with either the myelin basic protein peptide 85-99 (RTL303) or CABL-b3a2 (RTL311) peptides were constructed to provide a minimal ligand for peptide-specific TCRs… CONTINUE READING

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References

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Showing 1-10 of 30 references

09/847,172

  • U. S. Paten
  • Recombinant MHC molecules useful for manipulation…
  • 2001

6,270,772

  • U. S. Paten
  • Recombinant MHC molecules useful for the…
  • 2001

Differential susceptibility of human Th1 versus Th2 cells to induction of anergy and apoptosis by ECD1/antigen-coupled antigen-presenting cells

  • A. A. Vandenbark, D. Barnes, +9 authors Y. K. Chou
  • Int. Immunol
  • 2000

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