Rubidium chloride ingestion by volunteer subjects: Initial experience

  title={Rubidium chloride ingestion by volunteer subjects: Initial experience},
  author={R. Fieve and H. Meltzer and R. Taylor},
The authors report on the first metabolically controlled study of rubidium chloride administered to humans. Four subjects were given doses of 8.2–12.4 meq. RbCl in a single day, and biological half lives calculated from urinary excretion ranged from 21–55 days. A long term study of chronic rubidium loading in one of these subjects demonstrated no undesirable clinical side effects. After ingestion of a total dose of 268 meq. within a period of 75 days a plasma level of 0.16 meq./liter rubidium… Expand
Electrolytes, Renal Function, and Rubidium Chloride Therapy Side Effects
Rb was discovered by Kirchof and Bunsen in 1861. Widely distributed throughout nature (Perelman 1965) and animal tissues (Bertrand and Bertrand 1946) it belongs to the group 1A alkali metals justExpand
Effects of Rubidium Chloride on the Course of Manic-Depressive Illness 1
It seems that rubidium tends to increase the length of manic phases and possibly reduces the extremes of mood, but it has a long biological half-life and caution is still required. Expand
Clinical Investigations on the Efficacy and Tolerability of Rubidium Chloride
Rubidium (atomic number 37, atomic weight 85.47), discovered in 1861 by Kirchof and Bunsen, is an alkali metal belonging to the same periodic series as sodium, potassium, cesium, and lithium (MeltzerExpand
The use of rubidium chloride in depressive disorders: clinical aspects
Rubidium, discovered in 1861, by Bunsen and Kirchoff, is one of the Group 1 A alkali metals belonging to the same periodic series as lithium, sodium, potassium and cesium. It is widely distributed inExpand
Cerebrospinal fluid rubidium metabolism in depression
In 5 patients who received oral loading doses of rubidium, the steady state relationships between rubidium and potassium were altered and the increases in plasma and erythrocyte rubidium concentrations were greater than the increase in CSF rubidium concentration. Expand
Preliminary results with rubidium in depressed patients
This study studied 25 depressed patients resistant to other treatments, affected by either unipolar or bipolar syndromes, and found a slight beneficial effect of the salt on emotional withdrawal and motor retardation without producing any toxic reaction or altering EEG, EKG, or routine laboratory tests. Expand
Rubidium (Rb) treatment of rats: biological effects and implications for psychiatry.
The forced swimming test (FST), used to evaluate the effects on rats of treatment with Rb, was conducted after 1 or 3 mEq/kg Rb was given chronically or subacutely and antidepressant effects were not observed. Expand
Urinary rubidium in breast cancers.
  • Yi Su, Li-juan Chen, +9 authors Z. Ren
  • Medicine
  • Clinica chimica acta; international journal of clinical chemistry
  • 2011
The urinary levels of rubidium were significantly and inversely associated with risk of breast cancer and had potential to be a biomarker for breast cancer risk assessment. Expand
Lithium Prophylaxis and Experimental Rubidium Therapy in Affective Disorders
Lithium is the first drug for which a clear-cut prophylactic action against one of the major psychoses has been demonstrated. Expand
Effects of cesium on cellular systems
A knowledge of the biochemistry of Cs § thus became necessary in devising methods for reducing the body content of radioactive Cs + (2). Expand


In vivo experiment on the metabolism of cesium in human blood with reference to rubidium and potassium.
The different feature of blood metabolism found in the alkali elements was interpreted by the slow rate of clearance of ingested cesium from blood. Expand
The concentration of common cesium and rubidium in human body.
  • N. Yamagata
  • Chemistry, Medicine
  • Journal of radiation research
  • 1962
A fairly good agreement is observed in rubidium data with those reported by other workers, however, discrepancy in cesium data is observed between the author and other workers. Expand
Comparative studies of 132Cs and 86Rb turn-over in man using a double-tracer method.
The results suggest that Cs must have a different metabolic pathway to that of Rb, and that effective elimination of 137Cs from the human body can be made by some means when applied before 3 days after accidental 137Cs intake. Expand
A comparison of the distribution of 42K and 86Rb in rabbit and man
The rates of disappearance of the two isotopes from the plasma after intravenous injections in man are similar and an equilibrium of distribution is not attained within the period of study possible after injection of a tracer dose. Expand
The use of lithium in affective disorders. I. Acute endogenous depression.
After two to three weeks, there was evidence of a moderate to strong antidepressant effect of imipramine, while lithium produced only a weak to mild antidepressant effect. Expand
Brain norepinephrine: Enhanced turnover after rubidium treatment
In the report "Brain norepinephrine: Enhanced turnover after rubidium treatment" by J. M. Stolk et al. (24 April, p. 501), the second sentence of paragraph 1, column 1, page 501, should read "TheExpand
Rubidium: a Potential Modifier of Affect and Behaviour
Lithium does reduce manic hyperactivity and elation, however; thus its therapeutic use in the manic phase of manic depressive psychosis is limited, and a substance capable of producing similar improvements in the depressive phase remains to be discovered. Expand
Rubidium iodide
  • 1991
Multiple measures of behavior and metabolism in interdisciplinary research
  • 1967
Experimental electrocardiographic studies in the dog on the influence of alkali ions Li + , Na + , K + , Rb + and Cs +
  • Z . Biol .
  • 1966