Rubidium chloride ingestion by volunteer subjects: Initial experience

  title={Rubidium chloride ingestion by volunteer subjects: Initial experience},
  author={Ronald R. Fieve and Herbert L. Meltzer and Reginald Morton Taylor},
The authors report on the first metabolically controlled study of rubidium chloride administered to humans. Four subjects were given doses of 8.2–12.4 meq. RbCl in a single day, and biological half lives calculated from urinary excretion ranged from 21–55 days. A long term study of chronic rubidium loading in one of these subjects demonstrated no undesirable clinical side effects. After ingestion of a total dose of 268 meq. within a period of 75 days a plasma level of 0.16 meq./liter rubidium… 

Electrolytes, Renal Function, and Rubidium Chloride Therapy Side Effects

The first human clinical use of Rb and its effect on ten cardiac patients was described by Botkin in 1988; a subjective sense of well-being associated with increased blood pressure and decreased pulse rate was reported.

Effects of Rubidium Chloride on the Course of Manic-Depressive Illness 1

It seems that rubidium tends to increase the length of manic phases and possibly reduces the extremes of mood, but it has a long biological half-life and caution is still required.

Clinical Investigations on the Efficacy and Tolerability of Rubidium Chloride

Rubidium (atomic number 37, atomic weight 85.47), discovered in 1861 by Kirchof and Bunsen, is an alkali metal belonging to the same periodic series as sodium, potassium, cesium, and lithium (Meltzer

The use of rubidium chloride in depressive disorders: clinical aspects

Rubidium, discovered in 1861, by Bunsen and Kirchoff, is one of the Group 1 A alkali metals belonging to the same periodic series as lithium, sodium, potassium and cesium. It is widely distributed in

Cerebrospinal fluid rubidium metabolism in depression

In 5 patients who received oral loading doses of rubidium, the steady state relationships between rubidium and potassium were altered and the increases in plasma and erythrocyte rubidium concentrations were greater than the increase in CSF rubidium concentration.

Preliminary results with rubidium in depressed patients

This study studied 25 depressed patients resistant to other treatments, affected by either unipolar or bipolar syndromes, and found a slight beneficial effect of the salt on emotional withdrawal and motor retardation without producing any toxic reaction or altering EEG, EKG, or routine laboratory tests.

Urinary rubidium in breast cancers.

  • Yi SuLi-Juan Chen Z. Ren
  • Medicine
    Clinica chimica acta; international journal of clinical chemistry
  • 2011

Lithium Prophylaxis and Experimental Rubidium Therapy in Affective Disorders

Lithium is the first drug for which a clear-cut prophylactic action against one of the major psychoses has been demonstrated.

Effects of cesium on cellular systems

A knowledge of the biochemistry of Cs § thus became necessary in devising methods for reducing the body content of radioactive Cs + (2).

Rubidium Chloride in Recurrent Depression: Clinical and Biological Correlates

Rubidium, an alkali metal, has been used for over a century in human therapy in the form of rubidium salts, but it has only recently been introduced in psychiatric pharmacology (DeAngelis et al.



In vivo experiment on the metabolism of cesium in human blood with reference to rubidium and potassium.

The different feature of blood metabolism found in the alkali elements was interpreted by the slow rate of clearance of ingested cesium from blood.

The concentration of common cesium and rubidium in human body.

A fairly good agreement is observed in rubidium data with those reported by other workers, however, discrepancy in cesium data is observed between the author and other workers.

Comparative studies of 132Cs and 86Rb turn-over in man using a double-tracer method.

The results suggest that Cs must have a different metabolic pathway to that of Rb, and that effective elimination of 137Cs from the human body can be made by some means when applied before 3 days after accidental 137Cs intake.

A comparison of the distribution of 42K and 86Rb in rabbit and man

The rates of disappearance of the two isotopes from the plasma after intravenous injections in man are similar and an equilibrium of distribution is not attained within the period of study possible after injection of a tracer dose.

The use of lithium in affective disorders. I. Acute endogenous depression.

After two to three weeks, there was evidence of a moderate to strong antidepressant effect of imipramine, while lithium produced only a weak to mild antidepressant effect.

Brain norepinephrine: Enhanced turnover after rubidium treatment

In the report "Brain norepinephrine: Enhanced turnover after rubidium treatment" by J. M. Stolk et al. (24 April, p. 501), the second sentence of paragraph 1, column 1, page 501, should read "The

Rubidium: a Potential Modifier of Affect and Behaviour

Lithium does reduce manic hyperactivity and elation, however; thus its therapeutic use in the manic phase of manic depressive psychosis is limited, and a substance capable of producing similar improvements in the depressive phase remains to be discovered.

Rubidium iodide

  • 1991