Rubbish DNA: The Functionless Fraction of the Human Genome

@article{Graur2017RubbishDT,
  title={Rubbish DNA: The Functionless Fraction of the Human Genome},
  author={D. Graur},
  journal={arXiv: Genomics},
  year={2017},
  pages={19-60}
}
  • D. Graur
  • Published 2017
  • Biology
  • arXiv: Genomics
  • Because genomes are products of natural processes rather than “intelligent design,” all genomes contain functional and nonfunctional parts. The fraction of the genome that has no biological function is called “rubbish DNA.” Rubbish DNA consists of “junk DNA,” i.e., the fraction of the genome on which selection does not operate, and “garbage DNA,” i.e., sequences that lower the fitness of the organism but exist in the genome because purifying selection is neither omnipotent nor instantaneous. In… CONTINUE READING
    4 Citations

    References

    SHOWING 1-10 OF 191 REFERENCES
    An Evolutionary Classification of Genomic Function
    • 56
    • PDF
    The Case for Junk DNA
    • 165
    • Highly Influential
    • PDF
    Can ENCODE tell us how much junk DNA we carry in our genome?
    • D. Niu, L. Jiang
    • Biology, Medicine
    • Biochemical and biophysical research communications
    • 2013
    • 82
    • Highly Influential
    • PDF
    The Evolution of genome size
    • 387
    Skeletal DNA and the evolution of genome size.
    • 123
    Defining functional DNA elements in the human genome
    • 546
    • PDF
    On "genomenclature": a comprehensive (and respectful) taxonomy for pseudogenes and other "junk DNA".
    • J. Brosius, S. Gould
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1992
    • 292
    • PDF