Rtt109 Acetylates Histone H3 Lysine 56 and Functions in DNA Replication

  title={Rtt109 Acetylates Histone H3 Lysine 56 and Functions in DNA Replication},
  author={J. Han and H. Zhou and B. Horazdovsky and K. Zhang and R. Xu and Z. Zhang},
  pages={653 - 655}
  • J. Han, H. Zhou, +3 authors Z. Zhang
  • Published 2007
  • Biology, Medicine
  • Science
  • Acetylation of histone H3 lysine 56 (H3-K56) occurs in S phase, and cells lacking H3-K56 acetylation are sensitive to DNA-damaging agents. However, the histone acetyltransferase (HAT) that catalyzes global H3-K56 acetylation has not been found. Here we show that regulation of Ty1 transposition gene product 109 (Rtt109) is an H3-K56 HAT. Cells lacking Rtt109 or expressing rtt109 mutants with alterations at a conserved aspartate residue lose H3-K56 acetylation and exhibit increased sensitivity… CONTINUE READING
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