Rtr1 is a CTD phosphatase that regulates RNA polymerase II during the transition from serine 5 to serine 2 phosphorylation.

@article{Mosley2009Rtr1IA,
  title={Rtr1 is a CTD phosphatase that regulates RNA polymerase II during the transition from serine 5 to serine 2 phosphorylation.},
  author={Amber L Mosley and Samantha G Pattenden and Michael Carey and Swaminathan Venkatesh and Joshua M. Gilmore and Laurence Florens and Jerry L. Workman and Michael P Washburn},
  journal={Molecular cell},
  year={2009},
  volume={34 2},
  pages={168-78}
}
Messenger RNA processing is coupled to RNA polymerase II (RNAPII) transcription through coordinated recruitment of accessory proteins to the Rpb1 C-terminal domain (CTD). Dynamic changes in CTD phosphorylation during transcription elongation are responsible for their recruitment, with serine 5 phosphorylation (S5-P) occurring toward the 5' end of genes and serine 2 phosphorylation (S2-P) occurring toward the 3' end. The proteins responsible for regulation of the transition state between S5-P… CONTINUE READING
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Hyperphosphorylation of the C-terminal repeat domain of RNA polymerase II facilitates dissociation of its complex with mediator

  • T. Max, M. Sogaard, J. Q. Svejstrup
  • J. Biol. Chem. 282, 14113–14120.
  • 2007
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