RssAB-FlhDC-ShlBA as a major pathogenesis pathway in Serratia marcescens.

  title={RssAB-FlhDC-ShlBA as a major pathogenesis pathway in Serratia marcescens.},
  author={Chuan-Sheng Lin and Jim-Tong Horng and Chun-Hung Yang and Yu-Huan Tsai and L H Su and C L Wei and Chang-Chieh Chen and Shang-Chen Hsieh and Chia-Chen Lu and H C Lai},
  journal={Infection and immunity},
  volume={78 11},
Serratia marcescens has long been recognized as an important opportunistic pathogen, but the underlying pathogenesis mechanism is not completely clear. Here, we report a key pathogenesis pathway in S. marcescens comprising the RssAB two-component system and its downstream elements, FlhDC and the dominant virulence factor hemolysin ShlBA. Expression of shlBA is under the positive control of FlhDC, which is repressed by RssAB signaling. At 37°C, functional RssAB inhibits swarming, represses… CONTINUE READING
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