Rsk1 mediates a MEK–MAP kinase cell survival signal

  title={Rsk1 mediates a MEK–MAP kinase cell survival signal},
  author={A. Shimamura and B. A. Ballif and S. A. Richards and J. Blenis},
  journal={Current Biology},
  • A. Shimamura, B. A. Ballif, +1 author J. Blenis
  • Published 2000
  • Biology, Medicine
  • Current Biology
  • BACKGROUND Growth factors activate an array of cell survival signaling pathways. Mitogen-activated protein (MAP) kinases transduce signals emanating from their upstream activators MAP kinase kinases (MEKs). The MEK-MAP kinase signaling cassette is a key regulatory pathway promoting cell survival. The downstream effectors of the mammalian MEK-MAP kinase cell survival signal have not been previously described. RESULTS We identify here a pro-survival role for the serine/threonine kinase Rsk1, a… CONTINUE READING
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