Rsc_cs_c4cs00048j 3..25

Abstract

The OPEP coarse-grained protein model has been applied to a wide range of applications since its first release 15 years ago. The model, which combines energetic and structural accuracy and chemical specificity, allows the study of single protein properties, DNA–RNA complexes, amyloid fibril formation and protein suspensions in a crowded environment. Here we first review the current state of the model and the most exciting applications using advanced conformational sampling methods. We then present the current limitations and a perspective on the ongoing developments.

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@inproceedings{Sterpone2014Rsc_cs_c4cs00048j3, title={Rsc_cs_c4cs00048j 3..25}, author={Fabio Sterpone and Simone Melchionna and Pierre Tuff{\'e}ry and Samuela Pasquali and Normand Mousseau and Tristan Cragnolini and Yassmine Chebaro and Jean-François St-Pierre and Maria Kalimeri and Alessandro Barducci and Yoann Laurin and Alex Tek and Marc Baaden and Phuong H. Nguyen and Philippe Derreumaux}, year={2014} }