Rs290487 of TCF7L2 gene is not associated with type 2 diabetes in Chinese Han population: a case control study and meta-analysis.

@article{Ren2013Rs290487OT,
  title={Rs290487 of TCF7L2 gene is not associated with type 2 diabetes in Chinese Han population: a case control study and meta-analysis.},
  author={Qian Ren and Jie Xiao and Xueyao Han and Yong Luo and Wenying Yang and Linong Ji},
  journal={Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association},
  year={2013},
  volume={121 9},
  pages={526-30}
}
AIMS rs290487 in TCF7L2 was originally identified to be associated with type 2 diabetes in Taiwan Chinese population. However, discrepancies were noted in subsequent replicated studies. So the aim of this study is to investigate the effect of rs290487 in TCF7L2 on genetic susceptibility of type 2 diabetes in a large sample of Chinese -population. RESULTS In meta analysis of 9 studies with 9 422 cases and 8 585 control subjects, no association was found between rs290487 and type 2 diabetes in… CONTINUE READING