Rrp6p controls mRNA poly(A) tail length and its decoration with poly(A) binding proteins.

@article{Schmid2012Rrp6pCM,
  title={Rrp6p controls mRNA poly(A) tail length and its decoration with poly(A) binding proteins.},
  author={Manfred Schmid and Mathias Bach Poulsen and Pawel Olszewski and Vicent Pelechano and Cyril Saguez and Ishaan Gupta and Lars M. Steinmetz and Claire Moore and Torben Heick Jensen},
  journal={Molecular cell},
  year={2012},
  volume={47 2},
  pages={267-80}
}
Poly(A) (pA) tail binding proteins (PABPs) control mRNA polyadenylation, stability, and translation. In a purified system, S. cerevisiae PABPs, Pab1p and Nab2p, are individually sufficient to provide normal pA tail length. However, it is unknown how this occurs in more complex environments. Here we find that the nuclear exosome subunit Rrp6p counteracts the… CONTINUE READING