Rrp6, rrp47 and cofactors of the nuclear exosome.

@article{Butler2010Rrp6RA,
  title={Rrp6, rrp47 and cofactors of the nuclear exosome.},
  author={James Scott Butler and Phil Mitchell},
  journal={Advances in experimental medicine and biology},
  year={2010},
  volume={702},
  pages={
          91-104
        }
}
This chapter reviews the present state of knowledge on the activity of enzymes that function with the RNA exosome in the nucleus. In this compartment, the exosome interacts physically and functionally with the exoribonuclease Rrp6 and several cofactors, most prominently Rrp47 and the TRAMP complex. These interactions decide the fate of RNA precursors from transcription through the formation of mature ribonucleoprotein particles (RNPs) and the export of the RNPs to the cytoplasm. The nuclear… CONTINUE READING
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