Rrp47p is an exosome-associated protein required for the 3' processing of stable RNAs.

@article{Mitchell2003Rrp47pIA,
  title={Rrp47p is an exosome-associated protein required for the 3' processing of stable RNAs.},
  author={P. C. Mitchell and Elisabeth Petfalski and Rym Houalla and Alexandre V Podtelejnikov and Matthias Mann and David Tollervey},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 19},
  pages={6982-92}
}
Related exosome complexes of 3'-->5' exonucleases are present in the nucleus and the cytoplasm. Purification of exosome complexes from whole-cell lysates identified a Mg(2+)-labile factor present in substoichiometric amounts. This protein was identified as the nuclear protein Yhr081p, the homologue of human C1D, which we have designated Rrp47p (for rRNA processing). Immunoprecipitation of epitope-tagged Rrp47p confirmed its interaction with the exosome and revealed its association with Rrp6p, a… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS