Rpn1 and Rpn2 coordinate ubiquitin processing factors at proteasome.

  title={Rpn1 and Rpn2 coordinate ubiquitin processing factors at proteasome.},
  author={Rina Rosenzweig and Vered Bronner and Daoning Zhang and David Fushman and Michael H. Glickman},
  journal={The Journal of biological chemistry},
  volume={287 18},
Substrates tagged with (poly)ubiquitin for degradation can be targeted directly to the 26 S proteasome where they are proteolyzed. Independently, ubiquitin conjugates may also be delivered by bivalent shuttles. The majority of shuttles attach to the proteasome through a ubiquitin-like domain (UBL) while anchoring cargo at a C-terminal polyubiquitin-binding domain(s). We found that two shuttles of this class, Rad23 and Dsk2, dock at two different receptor sites embedded within a single subunit… CONTINUE READING
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