RpiR homologues may link Staphylococcus aureus RNAIII synthesis and pentose phosphate pathway regulation.

@article{Zhu2011RpiRHM,
  title={RpiR homologues may link Staphylococcus aureus RNAIII synthesis and pentose phosphate pathway regulation.},
  author={Yefei Zhu and Renu Nandakumar and Marat R. Sadykov and Nandakumar Madayiputhiya and Thanh Luong and Rosmarie Gaupp and Chia Yen Lee and Greg A Somerville},
  journal={Journal of bacteriology},
  year={2011},
  volume={193 22},
  pages={
          6187-96
        }
}
Staphylococcus aureus is a medically important pathogen that synthesizes a wide range of virulence determinants. The synthesis of many staphylococcal virulence determinants is regulated in part by stress-induced changes in the activity of the tricarboxylic acid (TCA) cycle. One metabolic change associated with TCA cycle stress is an increased concentration of ribose, leading us to hypothesize that a pentose phosphate pathway (PPP)-responsive regulator mediates some of the TCA cycle-dependent… CONTINUE READING

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