Royalactin induces queen differentiation in honeybees

@article{Kamakura2011RoyalactinIQ,
  title={Royalactin induces queen differentiation in honeybees},
  author={Masaki Kamakura},
  journal={Nature},
  year={2011},
  volume={473},
  pages={478-483}
}
The honeybee (Apis mellifera) forms two female castes: the queen and the worker. This dimorphism depends not on genetic differences, but on ingestion of royal jelly, although the mechanism through which royal jelly regulates caste differentiation has long remained unknown. Here I show that a 57-kDa protein in royal jelly, previously designated as royalactin, induces the differentiation of honeybee larvae into queens. Royalactin increased body size and ovary development and shortened… 

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...

References

SHOWING 1-10 OF 74 REFERENCES

Induction of caste differentiation in the honeybee (Apis mellifera) by juvenile hormone

TLDR
Differences in the volume and activity of the corpora allata of queen and worker larvae suggest that juvenile hormone may piny an important role in caste dimorphism of the bee; but, so far no conclusive evidence has been obtained.

The Making of a Queen: TOR Pathway Is a Key Player in Diphenic Caste Development

TLDR
The results present the first evidence for a role of TOR in diphenic development, and suggest that adoption of this ancestral nutrient-sensing cascade is one evolutionary pathway for morphological caste differentiation in social insects.

The early establishment of dimorphism in the female honeybee,Apis mellifera L.

TLDR
It is suggested that a difference in hormonal balance between castes is established in early larval life and is the intermediary factor linking nutrition to dimorphism.

Effects of Larval Age on Dimorphic Differentiation of the Female Honey Bee

TLDR
The female honey bee is potentially polymorphic, and some mechanism must operate to maintain the fairly strict dimorphism found in nature.

Nutritional Control of Reproductive Status in Honeybees via DNA Methylation

TLDR
The results suggest that DNA methylation in Apis is used for storing epigenetic information, that the use of that information can be differentially altered by nutritional input, and that the flexibility of epigenetic modifications underpins, profound shifts in developmental fates, with massive implications for reproductive and behavioral status.

Influence of juvenile hormone on gravity orientation in the female honeybee larva (Apis mellifera L.)

  • R. Ebert
  • Biology
    Journal of comparative physiology
  • 2004
TLDR
The juvenile hormone titer not only controls the differentiation of morphological and anatomical caste characteristics but also affects the orientation behaviour of the spinning larva.

The regulation of the yolk protein genes, a family of sex differentiation genes in Drosophila melanogaster

  • M. Bownes
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 1994
TLDR
The expression of the yolk protein genes is not entirely controlled by the sex determination hierarchy, as several different regulatory pathways must interact to direct their correct sexual, temporal and spatial regulation during development.
...