Royal jelly protects against ultraviolet B-induced photoaging in human skin fibroblasts via enhancing collagen production.

@article{Park2011RoyalJP,
  title={Royal jelly protects against ultraviolet B-induced photoaging in human skin fibroblasts via enhancing collagen production.},
  author={Hye Min Park and Eunson Hwang and Kwang-gill Lee and Sang Mi Han and Yunhi Cho and Sun Yeou Kim},
  journal={Journal of medicinal food},
  year={2011},
  volume={14 9},
  pages={
          899-906
        }
}
Royal jelly (RJ) is a honeybee product containing proteins, carbohydrates, fats, free amino acids, vitamins, and minerals. As its principal unsaturated fatty acid, RJ contains 10-hydroxy-2-decenoic acid (10-HDA), which may have antitumor and antibacterial activity and a capacity to stimulate collagen production. RJ has attracted interest in various parts of the world for its pharmacological properties. However, the effects of RJ on ultraviolet (UV)-induced photoaging of the skin have not been… 

Figures from this paper

Royal jelly increases collagen production in rat skin after ovariectomy.

Royal jelly may protect against skin aging by enhancing collagen production in rats with ovariectomy-induced estrogen deficiency, and the amount of collagen recovered was close to the normal level.

Coriander leaf extract exerts antioxidant activity and protects against UVB-induced photoaging of skin by regulation of procollagen type I and MMP-1 expression.

This study examined whether CS ethanol extract has protective effects against UVB-induced skin photoaging in normal human dermal fibroblasts (NHDF) in vitro and in the skin of hairless mice in vivo and found that the activity of transcription factor activator protein-1 (AP-1) was also inhibited by CSE treatment.

Vigna angularis water extracts protect against ultraviolet b-exposed skin aging in vitro and in vivo.

Hot-water extract from VA (VAE) and its active component, rutin, were investigated to determine their antiphotoaging effects and VAE was found to have antioxidant activity.

Sauchinone, a lignan from Saururus chinensis, protects human skin keratinocytes against ultraviolet B-induced photoaging by regulating the oxidative defense system.

It is demonstrated that sauchinone protects skin keratinocytes through inhibition of extracellular signal-regulated kinase, c-Jun N-terminal kinases, and p38 MAPK signaling via upregulation of oxidative defense enzymes.

Royal Jelly: Chemistry, Storage and Bioactivities

Royal jelly has been known for centuries, but in the last 5-6 decades its systematic production and consumption has increased and its physicochemical properties, bio-active ingredients, storage stability and shelf life are summarized and updated.

Royal jelly-derived proteins enhance proliferation and migration of human epidermal keratinocytes in an in vitro scratch wound model

This is the first report that royal jelly may improve wound closure via MRJP-induced cellular proliferation and migration, and these proteins may be valuable lead compounds for the development of novel wound healing medications.

Enzyme-processed Korean Red Ginseng extracts protects against skin damage induced by UVB irradiation in hairless mice

It was found that dietary KRGE inhibited the UVB-induced formation of wrinkles, epidermal thickness, and skin dryness in hairless mice, suggesting that KRGE may be a promising agent for the treatment of skin photodamages.

A Comparative Study of Baby Immature and Adult Shoots of Aloe Vera on UVB‐Induced Skin Photoaging in vitro

The results suggest that BAE may potentially protect the skin from UVB‐induced damage more than AE, and type I procollagen and TGF‐β1 levels after UVB irradiation.

Bee-derived antibacterial peptide, defensin-1, promotes wound re-epithelialisation in vitro and in vivo

It is indisputably demonstrate that defensin-1, a regular but concentration variable factor found in honey and RJ, contributes to cutaneous wound closure by enhancing keratinocyte migration and MMP-9 secretion.
...

References

SHOWING 1-10 OF 26 REFERENCES

Identification of a Collagen Production-promoting Factor from an Extract of Royal Jelly and Its Possible Mechanism

HBRJ-CPF identified as 10H2DA promoted the collagen production of AA-2G-treated fibroblasts by inducing TGF-β1 production, which is an important factor for collagen production.

Possible involvement of gelatinases in basement membrane damage and wrinkle formation in chronically ultraviolet B-exposed hairless mouse.

Ultraviolet B-induced enhancement of gelatinase activity in the skin contributes to wrinkle formation through the destruction of basement membrane structure and dermal collagen in chronically ultraviolet B-exposed hairless mouse, and thus topical application of matrix metalloproteinase inhibitors may be an effective way to prevent ultraviolet B.

Protective effects of aucubin isolated from Eucommia ulmoides against UVB-induced oxidative stress in human skin fibroblasts.

Using the human skin fibroblast HS68 cell line, the photoprotective effects of aucubin from Eucommia ulmoides were investigated and it was suggested that aucubs might play an important role in the cellular defense mechanism against UV radiation-induced photoaging.

c-Jun-dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoic acid.

It is reported here that a single exposure to UV irradiation causes significant loss of procollagen synthesis in human skin, and pretreatment of skin with all-trans retinoic acid protects against both of these deleterious effects and may thereby retard premature skin aging.

UV‐induced DNA damage initiates release of MMP‐1 in human skin

UV damage to keratinocytes of the epidermis may participate in the destruction of collagen in the dermis by release of soluble mediators that signal fibroblasts to release MMP‐1, a hallmark of photoaging.

Regulation of type I procollagen and MMP-1 expression after single or repeated exposure to infrared radiation in human skin

10-Hydroxy-2-decenoic Acid, a Major Fatty Acid from Royal Jelly, Inhibits VEGF-induced Angiogenesis in Human Umbilical Vein Endothelial Cells

Findings indicate that 10HDA exerts an inhibitory effect on VEGF-induced angiogenesis, partly by inhibiting both cell proliferation and migration.

Augmentation of wound healing by royal jelly (RJ) in streptozotocin-diabetic rats.

Royal jelly possesses an anti-inflammatory action and is able to augment wound healing, but does not have an insulin-like action in streptozotocin-diabetic rats.

Inhibition of UVB‐mediated Oxidative Stress and Markers of Photoaging in Immortalized HaCaT Keratinocytes by Pomegranate Polyphenol Extract POMx

The results suggest that POMx protects HaCaT cells against UVB‐induced oxidative stress and markers of photoaging and could be a useful supplement in skin care products.

Photodamage to the cutaneous sensory nerves: role in photoaging and carcinogenesis of the skin?

  • F. LegatP. Wolf
  • Biology, Medicine
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
  • 2006
It is suggested that skin cell-derived nerve growth factor and skin nerve-derived neuropeptides such as substance P and calcitonin gene-related peptide may play a central role in intrinsic aging as well as extrinsic (photo-) aging of the skin.