Royal Jelly Inhibits the Production of Proinflammatory Cytokines by Activated Macrophages

  title={Royal Jelly Inhibits the Production of Proinflammatory Cytokines by Activated Macrophages},
  author={Keizo Kohno and Iwao Okamoto and Osamu Sano and Norie Arai and Kanso Iwaki and Masao Ikeda and Masashi Kurimoto},
  journal={Bioscience, Biotechnology, and Biochemistry},
  pages={138 - 145}
In this study, we have examined the anti-inflammatory actions of royal jelly (RJ) at a cytokine level. When supernatants of RJ suspensions were added to a culture of mouse peritoneal macrophages stimulated with lipopolysaccharide and IFN-γ, the production of proinflammatory cytokines, such as TNF-α, IL-6, and IL-1, was efficiently inhibited in a dose-dependent manner without having cytotoxic effects on macrophages. This suggests that RJ contains factor(s) responsible for the suppression of… 

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