Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor.

@article{Meroni1997RoxAN,
  title={Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor.},
  author={Germana Meroni and Alexandre Reymond and Myriam Alcalay and Giuseppe Borsani and Akira Tanigami and Rossana Tonlorenzi and Cristiana Lo Nigro and Silvia Messali and Massimo Zollo and D. H. Ledbetter and Roger Brent and Andrea Ballabio and Rosalba Carrozzo},
  journal={The EMBO journal},
  year={1997},
  volume={16 10},
  pages={2892-906}
}
Proteins of the Myc and Mad family are involved in transcriptional regulation and mediate cell differentiation and proliferation. These molecules share a basic-helix-loop-helix leucine zipper domain (bHLHZip) and bind DNA at the E box (CANNTG) consensus by forming heterodimers with Max. We report the isolation, characterization and mapping of a human gene and its mouse homolog encoding a new member of this family of proteins, named Rox. Through interaction mating and immunoprecipitation… CONTINUE READING

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