Routing misfolded proteins through the multivesicular body (MVB) pathway protects against proteotoxicity.

@article{Wang2011RoutingMP,
  title={Routing misfolded proteins through the multivesicular body (MVB) pathway protects against proteotoxicity.},
  author={Songyu Wang and Guillaume Thibault and Davis T W Ng},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 33},
  pages={
          29376-87
        }
}
The secretory pathway maintains multiple quality control checkpoints. Initially, endoplasmic reticulum-associated degradation pathways monitor protein folding to retain and eliminate aberrant products. Despite its broad client range, some molecules escape detection and traffic to Golgi membranes. There, a poorly understood mechanism termed Golgi quality control routes aberrant proteins for lysosomal/vacuolar degradation. To better understand Golgi quality control, we examined the processing of… CONTINUE READING
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