Routing MAP Kinase Cascades

@article{Elion1998RoutingMK,
  title={Routing MAP Kinase Cascades},
  author={Elaine A. Elion},
  journal={Science},
  year={1998},
  volume={281},
  pages={1625 - 1626}
}
  • E. Elion
  • Published 11 September 1998
  • Biology
  • Science
Cells need to convey information from signals on their surface to a variety of intracellular targets, including transcription factors, contractile proteins, and enzymes. To do so efficiently, they construct information pathways with enzymes called kinases, using the same enzymes over and over. But what prevents cross talk between pathways? In her Perspective, Elion discusses new results in this issue by Whitmarsh et al. and Schaeffer et al., who identify proteins that act as scaffolds in… 
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142 Citations
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38
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142 Citations

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TLDR
The underlying biochemical mechanisms through which specificity is generated during signal transduction are addressed, and the means by which signaling molecules may act in combination to generate complex biological responses are pursued.
Selectivity in overlapping MAP kinase cascades.
TLDR
This work addresses the question whether specificity of the cascades necessitates physical sequestration of these "promiscuous" kinases, and shows that in this model selective signal transduction is possible provided that there is an additional interaction at the MAP-kinase level.
MAP Kinase Modules in Signaling
JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors
TLDR
A protein, JLP (c-Jun NH2-terminal kinase-associated leucine zipper protein), is described, which acts as a scaffolding protein that brings MAPKs and their target transcription factors together for the execution of specific signaling pathways.
Regulation of G protein-initiated signal transduction in yeast: paradigms and principles.
TLDR
This review describes the signal transduction pathway used by budding yeast to respond to its peptide mating pheromones, comprised by receptors, a heterotrimeric G protein, and a protein kinase cascade all remarkably similar to counterparts in multicellular organisms.
The Ste 5 p scaffold
TLDR
MAPK cascade scaffolds are widely divergent, which suggests that they have evolved independently for the individual requirements of subsets of kinases and upstream activating events, particularly in instances in which the same protein kinase functions in more than one pathway.
Regulatory mechanisms of mitogen-activated kinase signaling
TLDR
This review of recent advances in understanding the regulation of MAPK cascades and the roles of MAP kinases and their regulators in development and in immune responses is summarized.
Organization and regulation of mitogen-activated protein kinase signaling pathways.
Mitogen-activated protein kinases.
TLDR
In conclusion, elucidating the activation status of the MAPK pathways may be a method to identify patients at risk for systemic inflammatory response syndrome/multiple organ dysfunction syndrome and manipulating the proper pathways may improve patients' outcomes.
Mitogen-activated protein kinases.
TLDR
In conclusion, elucidating the activation status of the MAPK pathways may be a method to identify patients at risk for systemic inflammatory response syndrome/multiple organ dysfunction syndrome and manipulating the proper pathways may improve patients' outcomes.
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