Routine performance and errors of 454 HLA exon sequencing in diagnostics

  title={Routine performance and errors of 454 HLA exon sequencing in diagnostics},
  author={Norbert Niklas and Johannes Pr{\"o}ll and Martin Danzer and Stephanie Stabentheiner and Katja Hofer and Christian Gabriel},
  booktitle={BMC Bioinformatics},
Next-generation sequencing (NGS) has changed genomics significantly. More and more applications strive for sequencing with different platforms. Now, in 2012, after a decade of development and evolution, NGS has been accepted for a variety of research fields. Determination of sequencing errors is essential in order to follow next-generation sequencing beyond research use only. This study describes the overall 454 system performance of using multiple GS Junior runs with an in-house established… CONTINUE READING
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