Routine culture‐based screening versus risk‐based management for the prevention of early‐onset group B streptococcus disease in the neonate: a systematic review

  title={Routine culture‐based screening versus risk‐based management for the prevention of early‐onset group B streptococcus disease in the neonate: a systematic review},
  author={Ella Kurz and Deborah Lee Davis},
  journal={JBI Database of Systematic Reviews and Implementation Reports},
  • Ella Kurz, D. Davis
  • Published 15 August 2014
  • Medicine
  • JBI Database of Systematic Reviews and Implementation Reports
Background Early‐onset group B streptococcus disease, recognized as the most common cause of early onset neonatal sepsis in developed countries, is transmitted vertically from the group B streptococcus carrier mother to the neonate in the peripartum. Accordingly, early‐onset group B streptococcus disease is prevented by halting the transmission of the microorganism from the mother to the infant. Two main methods, routine culture‐based screening and risk‐based management, may be used in the… 
Screening-based and Risk-based Strategy for the Prevention of Early-onset Group B Streptococcus/Non-group B Streptococcus Sepsis in the Neonate: A Systematic Review and Meta-analysis
Compared with risk-based strategy, screening-based prophylaxis was associated with a reduced risk of GBS-EOS.
Group B streptococcal screening, intrapartum antibiotic prophylaxis, and neonatal early-onset infection rates in an Australian local health district: 2006-2016
No change was detected in rates of EOGBS over time and no difference inEOGBS in babies of screened and unscreened populations, and Limitations of universal screening suggest alternatives be considered.
Universal screening versus risk‐based protocols for antibiotic prophylaxis during childbirth to prevent early‐onset group B streptococcal disease: a systematic review and meta‐analysis
Early‐onset group B streptococcal (EOGBS) disease (including sepsis, meningitis, and pneumonia) causes significant morbidity and mortality in newborn infants worldwide and no uniform criteria exist to identify eligible women for prophylaxis.
Utility of neonatal early-onset sepsis calculator in risk-based group B Streptococcus screening approach
  • M. Kim
  • Medicine
    Clinical and experimental pediatrics
  • 2020
The impact of GBS status when applying the EOS calculator in risk-based GBS screening is evaluated, as it calculates the GBS risk and recommends management at birth and after the recalculation of a definitive EOS status.
Protocol for a Diagnostic Accuracy Study of Polymerase Chain Reaction for Detecting Group B Streptococcus Colonisation in Early Labour or with Spontaneous Ruptured Membranes
This study will compare the diagnostic accuracy of Polymerase Chain Reaction screening and antenatal culture-based screening at 35 to 37 weeks gestational age, with the reference standard of formal culture- based testing in labour, to improve the accuracy of GBS screening of pregnant women.
Universal antenatal screening for group B streptococcus colonisation in the UK
GBS infection is an important health condition and its persistence, poor screening tests and the IAP harms stress the need for a better understanding of the natural history of GBS and more effective prevention, therefore, screening should not be introduced in the UK.
Neonatal Sepsis
A review of neonatal sepsis by identifying its associated risk factors and most common causative pathogens, reviewing features of the term and preterm neonatal immune systems that increase vulnerability to infection, describing previous and the most current management recommendations, and discussing relevant implications for the neonatal nurse and novice Neonatal nurse practitioner are provided.


Routine culture based screening versus risk based management for the prevention of early onset group B streptococcus disease in the neonate: a systematic review protocol
The effectiveness of routine culture based screening and risk based management in the prevention of early onset group B streptococcus disease (EOGBSD) morbidity and mortality in the neonate as well as compare rates of intrapartum antibiotic prophylaxis (IAP) in both groups is determined.
Prevention of Group B Streptococcus Early-onset Neonatal Sepsis: Comparison of the Center for Disease Control and Prevention Screening-Based Protocol to a Risk-Based Protocol in Infants at Greater Than 37 Weeks' Gestation
GBS screening at 35 to 37 weeks, with intrapartum antimicrobial prophylaxis of carriers, decreased the incidence of neonatal early-onset GBS sepsis and appears to have advantages over treatment based on risk factors alone in term infants.
Maternal colonisation with group B streptococcus and effectiveness of a culture‐based protocol to prevent early‐ onset neonatal sepsis
A culture plus individualised high‐ risk‐based antibiotic prophylaxis provided an insignificant change in neonatal colonisation and early‐onset neonatal sepsis with GBS when compared with high‐risk‐based approach alone.
A population-based comparison of strategies to prevent early-onset group B streptococcal disease in neonates.
Routine screening for group B streptococcus during pregnancy prevents more cases of early-onset disease than the risk-based approach, and recommendations that endorse both strategies as equivalent warrant reconsideration.
Beyond Screening: Identifying New Barriers to Early Onset Group B Streptococcal Disease Prevention
Challenges to implementation of group B streptococcal screening and prophylaxis include insufficient screening, suboptimal intrapartum antibiotics, disease despite negative screening cultures and timely communication of screening results at delivery.
Evaluation of universal antenatal screening for group B streptococcus.
Improved management of preterm deliveries and improved collection, processing, and reporting of culture results may prevent additional cases of early-onset group B streptococcal disease.
Early-onset group B streptococcal disease in the era of maternal screening.
Until effective vaccines against GBS are available for clinical use, development and implementation of rapid and sensitive techniques for screening for GBS status and antibiotic susceptibility at presentation may help prevent additional cases of invasive GBS disease.
Prevention of early-onset invasive neonatal group B streptococcal disease in a private hospital setting: the superiority of culture-based protocols.
In a large private tertiary care hospital, the approach based on maternal culture at 35 to 37 weeks' gestation and treatment during labor of all patients with positive results significantly reduced early-onset group B streptococcal infections without increasing infections from resistant organisms.
The prevention of neonatal group B streptococcal disease: a report by a working group of the Medical Screening Society
This review examines the published literature to assess the morbidity and mortality attributable to neonatal GBS infection, quantify the screening performance of the two alternative modes of screening, review the evidence on the efficacy of the vaccine, and estimate the numbers of deaths and cases of serious disability that each strategy in turn might prevent in the UK.
The Prevention of Early-Onset Neonatal Group B Streptococcal Disease.
  • D. Money, V. Allen
  • Medicine
    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
  • 2016