Routine clinical use of the one-step nucleic acid amplification assay for detection of sentinel lymph node metastases in breast cancer patients: results of a multicenter study in Japan.

@article{Tamaki2012RoutineCU,
  title={Routine clinical use of the one-step nucleic acid amplification assay for detection of sentinel lymph node metastases in breast cancer patients: results of a multicenter study in Japan.},
  author={Yasuhiro Tamaki and Nobuaki Sato and Keiichi Homma and Daisuke Takabatake and Rieko Nishimura and Masahiko Tsujimoto and Katsuhide Yoshidome and Hitoshi Tsuda and Takayuki Kinoshita and Hironori Kato and Kiyomi Taniyama and Takako Kamio and Seigo Nakamura and Futoshi Akiyama and Shinzaburo Noguchi},
  journal={Cancer},
  year={2012},
  volume={118 14},
  pages={3477-83}
}
BACKGROUND The objective of this study was to confirm, by means of a multicenter study conducted in Japan, the reliability and usefulness of the one-step nucleic acid amplification (OSNA) assay in routine clinical use for sentinel lymph node biopsy (SLNB) of breast cancer patients. METHODS Patients with Tis-T2N0M0 breast cancer who underwent SLNB before systemic chemotherapy comprised the study cohort. A whole sentinel lymph node (SLN) was examined intraoperatively with the OSNA assay except… CONTINUE READING
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