Routine analysis of IgVH mutational status in CLL patients using BIOMED-2 standardized primers and protocols.

Abstract

Current methods for the detection of IgVH mutational status in chronic lymphocytic leukemia (CLL), which identifies 2 subgroups of patients with significantly different outcomes, are laborious, expensive and do not lend themselves to a routine diagnostic setting. With the introduction of BIOMED-2 primers, a rapid protocol is now available. This study… (More)

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