Routine TP53 testing for breast cancer under age 30: ready for prime time?

@article{McCuaig2012RoutineTT,
  title={Routine TP53 testing for breast cancer under age 30: ready for prime time?},
  author={Jeanna M. McCuaig and Susan Armel and Ana Kundid Novokmet and O Ginsburg and Rochelle Demsky and Steven A Narod and David Malkin},
  journal={Familial Cancer},
  year={2012},
  volume={11},
  pages={607-613}
}
It is well known that early-onset breast cancer may be due to an inherited predisposition. When evaluating women diagnosed with breast cancer under age 30, two important syndromes are typically considered: Hereditary Breast and Ovarian Cancer Syndrome and Li-Fraumeni syndrome. Many women are offered genetic testing for mutations in the BRCA1 and BRCA2 genes; however, few are offered genetic testing for mutations in the TP53 gene. There is a concern that overly restrictive testing of TP53 may… CONTINUE READING

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