Route of monocyte differentiation determines their cytokine production profile: CD40 ligation induces interleukin 10 expression.

@article{Foey2000RouteOM,
  title={Route of monocyte differentiation determines their cytokine production profile: CD40 ligation induces interleukin 10 expression.},
  author={Andrew David Foey and Marc Feldmann and Fionula Mary Brennan},
  journal={Cytokine},
  year={2000},
  volume={12 10},
  pages={1496-505}
}
Interleukin 10 is a potent anti-inflammatory and immunomodulatory cytokine. Little is known regarding its induction in monocytes/macrophages, however LPS, a reproducible trigger of IL-10, is augmented by direct contact with T cells. In this context, the role of CD40-ligation is investigated. In the rheumatoid synovium, IL-10 is produced by tissue macrophages. Monocytes primed with M-CSF, a cytokine present in rheumatoid joints, produced IL-1beta, TNF-alpha and IL-10 upon CD40-ligation at an IL… CONTINUE READING
13 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Similar Papers

Loading similar papers…