Roundabout signaling pathway involved in the pathogenesis of COPD by integrative bioinformatics analysis

@article{Lin2019RoundaboutSP,
  title={Roundabout signaling pathway involved in the pathogenesis of COPD by integrative bioinformatics analysis},
  author={Yuanzhen Lin and Xiao-ning Zhong and X. Chen and Yi Liang and H. Zhang and Dong-Lan Zhu},
  journal={International Journal of Chronic Obstructive Pulmonary Disease},
  year={2019},
  volume={14},
  pages={2145 - 2162}
}
  • Yuanzhen Lin, Xiao-ning Zhong, +3 authors Dong-Lan Zhu
  • Published 2019
  • Medicine
  • International Journal of Chronic Obstructive Pulmonary Disease
  • Purpose To explore the potential mechanism underpinning the development of chronic obstructive pulmonary disease (COPD) and to investigate the role of the Roundabout signaling pathway in COPD. Methods Three microarray datasets (GSE1650, GSE38974 and GSE76925) including 139 cases of severe COPD and 52 cases of normal smokers without carcinoma, were integrated to screen differentially expressed genes (DEGs) using bioinformatics methods. Gene ontology (GO) annotations and Kyoto Encyclopedia of… CONTINUE READING
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