Rough Sheets and Smooth Tubules

@article{Shibata2006RoughSA,
  title={Rough Sheets and Smooth Tubules},
  author={Yoko Shibata and Gia K. Voeltz and Tom A. Rapoport},
  journal={Cell},
  year={2006},
  volume={126},
  pages={435-439}
}
The endoplasmic reticulum (ER) has distinct morphological domains composed of sheets and tubules, which differ in their characteristic membrane curvature. Key proteins may drive the formation of these structural morphologies, which in turn could generate the rough and smooth functional domains of the ER. 

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References

SHOWING 1-10 OF 57 REFERENCES
Structural organization of the endoplasmic reticulum
TLDR
The endoplasmic reticulum is a continuous membrane system but consists of various domains that perform different functions and how this is accomplished remains mysterious, but some insight has been gained from in vitro systems. Expand
Endoplasmic reticulum of animal cells and its organization into structural and functional domains.
TLDR
These processes involved in the establishment and maintenance of an anisotropic distribution of ER-resident proteins and, thus, in the organization of the ER into functionally and morphologically different subregions are outlined. Expand
Intermembrane bridges within membrane organelles revealed by quick‐freeze deep‐etch electron microscopy
TLDR
This work examined various kinds of cells by quick‐freeze deep‐etch electron microscopy to reveal the membranous attachments that support these shapes and relationships in intracellular membrane–bounded organelles. Expand
How proteins produce cellular membrane curvature
Biological membranes exhibit various function-related shapes, and the mechanism by which these shapes are created is largely unclear. Here, we classify possible curvature-generating mechanisms thatExpand
Dynamics and inheritance of the endoplasmic reticulum
TLDR
Analysis in budding yeast indicates that ER inheritance involves the polarized transport of cytoplasmic ER tubules into newly formed buds along actin cables by a type V myosin, which requires the Sec3p subunit of the exocyst complex. Expand
A Class of Membrane Proteins Shaping the Tubular Endoplasmic Reticulum
TLDR
This work has used an in vitro system to address the mechanism by which the tubular network of the endoplasmic reticulum (ER) is generated and maintained and proposes that these "morphogenic" proteins partition into and stabilize highly curved ER membrane tubules. Expand
The plant ER: a dynamic organelle composed of a large number of discrete functional domains.
  • L. Staehelin
  • Biology, Medicine
  • The Plant journal : for cell and molecular biology
  • 1997
The endoplasmic reticulum (ER) of plants is comprised of a three-dimensional network of continuous tubules and sheets that underlies the plasma membrane, courses through the cytoplasm, and links upExpand
In Vitro Formation of the Endoplasmic Reticulum Occurs Independently of Microtubules by a Controlled Fusion Reaction
TLDR
The results suggest that the ER network forms in a process in which cytosolic factors modify and regulate a basic reaction of membrane vesicle fusion, similar to formation of the nuclear envelope. Expand
Endoplasmic reticulum architecture: structures in flux.
TLDR
The mechanisms that modulate ER structure are likely to be important for the generation of the characteristic shapes of other organelles, as well as in response to alterations in cytosolic ion concentrations. Expand
Microtubules and the endoplasmic reticulum are highly interdependent structures
TLDR
It is concluded that microtubules and the ER are highly interdependent in two ways: polymerization of individual micro Tubules and extension of individual ER tubules occur together at the level of resolution of the fluorescence microscope, and depolymerization of micro Tubule leads to a slow retraction of the ER network towards the cell center, indicating that over longer periods of time, the extended state of the entire ER network requires the microtubule system. Expand
...
1
2
3
4
5
...