Rottlerin induces apoptosis via death receptor 5 (DR5) upregulation through CHOP-dependent and PKC delta-independent mechanism in human malignant tumor cells.

@article{Lim2008RottlerinIA,
  title={Rottlerin induces apoptosis via death receptor 5 (DR5) upregulation through CHOP-dependent and PKC delta-independent mechanism in human malignant tumor cells.},
  author={Jun Hee Lim and Jong-Wook Park and Kyeong Sook Choi and Yong Bok Suseong-gu Park and Taeg Kyu Kwon},
  journal={Carcinogenesis},
  year={2008},
  volume={30 5},
  pages={
          729-36
        }
}
Rottlerin has been shown to induce antiproliferation and apoptosis of human cancer cell lines. In this study, we demonstrate a novel mechanism of rottlerin-induced apoptosis via death receptor (DR) 5 upregulation. We found that treatment with rottlerin significantly induces DR5 expression both at its messenger RNA and protein levels. Downregulation of DR5 expression with small-interfering RNA (siRNA) efficiently attenuated rottlerin-induced apoptosis, showing that the critical role of DR5 in… CONTINUE READING

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Down - regulation of caspase - 2 by rottlerin via protein kinase C - delta - independent pathway

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