Rottlerin-induced BKCa channel activation impairs specific contractile responses and promotes vasodilation.

Abstract

BACKGROUND Activation of large conductance calcium-activated potassium (BKCa) channels is cardioprotective for ischemic injury and can enhance vasorelaxation. Rottlerin has recently been identified as a potent BKCa activator. We demonstrated that rottlerin improves cardiac function and increases coronary flow when used as a cardioplegia additive in rat and… (More)
DOI: 10.1016/j.athoracsur.2014.07.091

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Cite this paper

@article{Cordeiro2015RottlerininducedBC, title={Rottlerin-induced BKCa channel activation impairs specific contractile responses and promotes vasodilation.}, author={Brenda Cordeiro and Connor Shinn and Frank W. Sellke and Richard T. Clements}, journal={The Annals of thoracic surgery}, year={2015}, volume={99 2}, pages={626-34} }