Rottlerin dissolves pre-formed protein amyloid: a study on hen egg white lysozyme.

@article{Sarkar2011RottlerinDP,
  title={Rottlerin dissolves pre-formed protein amyloid: a study on hen egg white lysozyme.},
  author={Nandini Sarkar and Manjeet Kumar and Vikash Kumar Dubey},
  journal={Biochimica et biophysica acta},
  year={2011},
  volume={1810 9},
  pages={809-14}
}
BACKGROUND Deposition of protein fibrillar aggregates called amyloids in the tissue, is the principal cause of several degenerative diseases. Here, we have shown the disaggregation potential of rottlerin towards hen egg white lysozyme (HEWL) fibrils formed under alkaline conditions (pH-12.2). METHODS Several biophysical methods like Atomic force… CONTINUE READING