Rottlerin Inhibits ROS Formation and Prevents NFκB Activation in MCF-7 and HT-29 Cells

  title={Rottlerin Inhibits ROS Formation and Prevents NFκB Activation in MCF-7 and HT-29 Cells},
  author={Emanuela Maioli and Lucedio Greci and Karel Sou{\vc}ek and Martina H{\'y}{\vz}ďalov{\'a} and Alessandra Pecorelli and Vittoria Fortino and Giuseppe Valacchi},
  booktitle={Journal of biomedicine & biotechnology},
Rottlerin, a polyphenol isolated from Mallotus Philippinensis, has been recently used as a selective inhibitor of PKC delta, although it can inhibit many kinases and has several biological effects. Among them, we recently found that Rottlerin inhibits the Nuclear Factor kappaB (NFkappaB), activated by either phorbol esters or H(2)O(2). Because of the redox sensitivity of NFkappaB and on the basis of Rottlerin antioxidant property, we hypothesized that Rottlerin could prevent NFkappaB activation… CONTINUE READING
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