Rotigotine protects against glutamate toxicity in primary dopaminergic cell culture.

@article{Oster2014RotigotinePA,
  title={Rotigotine protects against glutamate toxicity in primary dopaminergic cell culture.},
  author={Sandra Oster and Khaled S. Radad and Dieter K Scheller and Marlen Hesse and Wladimir Balanzew and Heinz Reichmann and Gabriele Gille},
  journal={European journal of pharmacology},
  year={2014},
  volume={724},
  pages={31-42}
}
In Parkinson disease the degeneration of dopaminergic neurones is believed to lead to a disinhibition of the subthalamic nucleus thus increasing the firing rate of the glutamatergic excitatory projections to the substantia nigra. In consequence, excessive glutamatergic activity will cause excitotoxicity and oxidative stress. In the present study we investigated mechanisms of glutamate toxicity and the neuroprotective potential of the dopamine agonist rotigotine towards dopaminergic neurones in… CONTINUE READING